IPAS Antifugal Research featured in ACS Catalysis
Fungal infections are a serious risk-factor faced by hospital patients who have compromised immune-systems, such as those undergoing organ or bone-marrow transplants, chemotherapy, or those with HIV/AIDS. Fungi rely on specific enzymes to build and maintain a strong and well-functioning cell membrane. We have taken an atomic-resolution snapshot of one such enzyme in action, such that we can now see the full process by which it catalyses the first step in the synthesis of an essential cell-membrane component. This information is invaluable for understanding how fungi survive and grow, and useful for considering when designing new antifungal medications.
Structure of Aspergillus fumigatus Cytosolic Thiolase: Trapped Tetrahedral Reaction Intermediates and Activation by Monovalent Cations.
Andrew C. Marshall, Charles S. Bond‡, and John B. Bruning
ACS Catal., 2018, 8 (3), pp 1973–1989