Simultaneous observation of the metabolism of cisplatin and NAMI-A in human plasma in vitro by SEC-ICP-AES
Summary: The binding of two different anticancer drugs, NAMI A and cisplatin, to blood plasma proteins showed that both bind to the same protein yet their respective metabolism went unchanged. Single drug-based treatments are regularly hindered by the development of drug resistance by the cancer. Combination therapy, or the use of multiple drugs during treatment, but they must not interfere with each other negatively, thus therapy with these drugs warrants further trials.
Authors: Sooriyaarachchi, M, Wedding, JL, Harris, HH, Gailer, J
Work done in collaboration with University of Calgary