Claire Weekley investigates why cells die when they are exposed to selenite
Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se-Cu bonding
In cells treated with selenite, reactive oxygen species are produced and eventually lead to cell death. Associated with this is an increase in the concentration of Cu/Zn-SOD, an increase in the concentration of Cu and the formation of Cu-Se bonds. This is the first time the formation of Cu-Se bonds has been shown in selenite-treated cells.
Authors: Weekley, CM, Jeong, G, Tierney, ME, Hossain, F, Maw, AM, Shanu, A, Harris, HH, Witting, PK
Journal of Biological Inorganic Chemistry in press (2014)
Work done in collaboration with The University of Sydney