Claire Weekley investigates why cells die when they are exposed to selenite

Claire Weekley (2)

Selenite-mediated production of superoxide radical anions in A549 cancer cells is accompanied by a selective increase in SOD1 concentration, enhanced apoptosis and Se-Cu bonding

In cells treated with selenite, reactive oxygen species are produced and eventually lead to cell death. Associated with this is an increase in the concentration of Cu/Zn-SOD, an increase in the concentration of Cu and the formation of Cu-Se bonds. This is the first time the formation of Cu-Se bonds has been shown in selenite-treated cells.

Authors: Weekley, CM, Jeong, G, Tierney, ME, Hossain, F, Maw, AM, Shanu, A, Harris, HH, Witting, PK

Journal of Biological Inorganic Chemistry in press (2014)

Work done in collaboration with The University of Sydney

JBIC-2014 Graphic

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Posted on March 26, 2014, in IPASnews, Paper Summaries. Bookmark the permalink. Leave a comment.

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